Brognard LZK PROTACs

Agency: HEALTH AND HUMAN SERVICES, DEPARTMENT OF
State: Maryland
Type of Government: Federal
Category:
  • 66 - Instruments and Laboratory Equipment
Posted: Dec 1, 2021
Due: Dec 11, 2022
Solicitation No: NHBLI-RTB-22-003172
Publication URL: To access bid details, please log in.
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Brognard LZK PROTACs
Active
Contract Opportunity
Notice ID
NHBLI-RTB-22-003172
Related Notice
Department/Ind. Agency
HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Sub-tier
NATIONAL INSTITUTES OF HEALTH
Office
NATIONAL INSTITUTES OF HEALTH NHLBI
General Information
  • Contract Opportunity Type: Combined Synopsis/Solicitation (Original)
  • All Dates/Times are: (UTC-05:00) EASTERN STANDARD TIME, NEW YORK, USA
  • Original Published Date: Dec 01, 2021 01:30 pm EST
  • Original Date Offers Due: Dec 11, 2022
  • Inactive Policy: 15 days after date offers due
  • Original Inactive Date: Dec 26, 2022
  • Initiative:
    • None
Classification
  • Original Set Aside:
  • Product Service Code: 6640 - LABORATORY EQUIPMENT AND SUPPLIES
  • NAICS Code: 325199 - All Other Basic Organic Chemical Manufacturing
  • Place of Performance:
    Bethesda , MD 20892
    USA
Description

The Chemistry and Synthesis Center (CSC) was initiated in the incubator space of the Common Fund and has transitioned to the intramural program of the National Heart, Lung, and Blood Institute. It is dedicated to the production of new chemical tools for the intramural NIH research community. CSC is administered by the National Heart, Lung, and Blood Institute for the benefit of the entire community of intramural NIH scientists, and is already working on projects for requesting scientists from more than a dozen NIH Institutes. CSC is working on an ongoing project to develop novel and selective inhibitors of an obscure but important kinase. These inhibitors are projected to be useful directly in the potential treatment of head and neck cancers, and may be further leveraged as the basis for targeted degraders. However, the project has grown to the point where we no longer have sufficient capacity to synthesize as many compounds as needed to understand the structure-activity relationship between kinase and inhibitors. Therefore outside synthetic support is necessary to generate this set of 10 compounds. Description of compounds in Attachment 1.


Attachments/Links
Contact Information
Contracting Office Address
  • 6701 ROCKLEDGE DRIVE ROOM 6100
  • BETHESDA , MD 20892
  • USA
Primary Point of Contact
Secondary Point of Contact


History
  • Dec 01, 2021 01:30 pm ESTCombined Synopsis/Solicitation (Original)
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