Protein ENGineering (PENG)

Location: Federal
Posted: Aug 7, 2026
Due: Oct 19, 2026
Agency: DEPT OF DEFENSE
Type of Government: Federal
Category:
  • A - Research and development
Solicitation No: DARPA-PS-26-129
Publication URL: To access bid details, please log in.
Follow
Protein ENGineering (PENG)
Active
Contract Opportunity
Notice ID
DARPA-PS-26-129
Related Notice
Department/Ind. Agency
DEPT OF DEFENSE
Sub-tier
DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
Office
DEF ADVANCED RESEARCH PROJECTS AGCY
Looking for contract opportunity help?

APEX Accelerators are an official government contracting resource for small businesses. Find your local APEX Accelerator (opens in new window) for free government expertise related to contract opportunities.

APEX Accelerators are funded in part through a cooperative agreement with the Department of Defense.

The APEX Accelerators program was formerly known as the Procurement Technical Assistance Program (opens in new window) (PTAP).

General Information
  • Contract Opportunity Type: Solicitation (Original)
  • Original Published Date: Aug 07, 2026 11:37 am EDT
  • Original Date Offers Due: Oct 19, 2026 04:00 pm EDT
  • Inactive Policy: Manual
  • Original Inactive Date: Nov 18, 2026
  • Initiative:
    • None
Classification
  • Original Set Aside:
  • Product Service Code: AC12 - NATIONAL DEFENSE R&D SERVICES; DEPARTMENT OF DEFENSE - MILITARY; APPLIED RESEARCH
  • NAICS Code:
    • 541714 - Research and Development in Biotechnology (except Nanobiotechnology)
  • Place of Performance:
Description
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline.

The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.
Attachments/Links
Contact Information
Contracting Office Address
  • 675 NORTH RANDOLPH STREET
  • ARLINGTON , VA 222032114
  • USA
Primary Point of Contact
Secondary Point of Contact


History
  • Aug 07, 2026 11:37 am EDTSolicitation (Original)

Related Document

Aug 21, 2026[Solicitation (Updated)] Protein ENGineering (PENG)
Daily notification on new contract opportunities

With GovernmentContracts, you can:

  • Find more opportunities and win more business
  • Receive daily alerts for all new bid opportunities
  • Get contract opportunities matched to your business
ONE WEEK FREE TRIAL

See also

ECONOMIC CRIMES TEAM ADVISOR ...

...writing skills, including the use of editing tools. Proficient in use of personal ...

TREASURY, DEPARTMENT OF THE

Bid Due: 12/31/2026

* Disclaimer: Information regarding bids, requests for proposals (RFPs), or requests for qualifications (RFQs) is provided on this website only for convenience and does not constitute official public notice. Persons wishing to respond to or inquire about bids, RFPs, or RFQs should contact the appropriate government department.
© 2000-2026 GovernmentContracts. All rights reserved.