Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)
| Location: | Federal |
|---|---|
| Posted: | May 21, 2026 |
| Due: | May 28, 2026 |
| Agency: | HEALTH AND HUMAN SERVICES, DEPARTMENT OF |
| Type of Government: | Federal |
| Category: |
|
| Solicitation No: | ARPA-H-SOL-26-139 |
| Publication URL: | To access bid details, please log in. |
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- Contract Opportunity Type: Solicitation (Updated)
- Updated Published Date: May 21, 2026 04:29 pm EDT
- Original Published Date: Feb 17, 2026 12:50 pm EST
- Updated Date Offers Due: May 28, 2026 01:00 pm EDT
- Original Date Offers Due: May 29, 2026 01:00 pm EDT
- Inactive Policy: 15 days after date offers due
- Updated Inactive Date: Jun 12, 2026
- Original Inactive Date: Jun 13, 2026
-
Initiative:
- None
- Original Set Aside: No Set aside used
- Product Service Code: AN13 - HEALTH R&D SERVICES; HEALTH CARE SERVICES; EXPERIMENTAL DEVELOPMENT
-
NAICS Code:
- 541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
-
Place of Performance:
USA
The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement.
CIRCLE seeks to create a critical illness Control Point Validation Engine that leads to improvements in intensive care unit (ICU) health outcomes, coupled to reduced stay time and associated costs, by assessing, predicting, and treating immuno-inflammatory dysregulation before it causes organ failure.
Interested parties are invited to review the attached CIRCLE ISO ARPA-H-SOL-26-139 and its Attachments A – F.
Proposer's Day: Wednesday, March 11, 2026 (ARPA-H-SN-26-149)
Solution Summaries Due: Monday, March 30, 2026, 1 PM ET (to https://solutions.arpa-h.gov)
Questions Due: Friday, May 22, 2026, 1 PM ET (to https://solutions.arpa-h.gov/Ask-A-Question/)
Full Proposals Due: Thursday, May 28, 2026, 1 PM ET (to https://solutions.arpa-h.gov)
ARPA-H will not reimburse potential proposers for time and effort related to submission of solution summaries or proposals. When planning a response to this notice, proposers should consider that some parts of the submission process may take from one business day to one month to complete.
-------------------------- Amendment 1 --------------------------
The purpose of this amendment is to: change the proposal submission date to Thursday, May 28, 2026 and replace Office of Commercialization (OC) with ARPA-H.
-------------------------- Amendment 2 --------------------------
The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.
-------------------------- Amendment 3 --------------------------
The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.
-------------------------- Amendment 4 --------------------------
The purpose of this amendment is to provide revisions as highlighed in yellow in the attached documents.
- 1301 K Street NW Suite 1200 West
- Washington , DC 20005
- USA
- ARPA-H RSO CIRCLE ISO Coordinator
- CIRCLE@ARPA-H.gov
- May 21, 2026 04:29 pm EDTSolicitation (Updated)
- Apr 28, 2026 05:28 pm EDT Solicitation (Updated)
- Mar 23, 2026 04:16 pm EDT Solicitation (Updated)
- Feb 20, 2026 10:27 am EST Solicitation (Updated)
- Feb 17, 2026 12:50 pm EST Solicitation (Original)
Related Document
| Feb 17, 2026 | [Solicitation (Original)] Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO) |
| Feb 21, 2026 | [Solicitation (Updated)] Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO) |
| Mar 23, 2026 | [Solicitation (Updated)] Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO) |
| Apr 28, 2026 | [Solicitation (Updated)] Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO) |
| May 26, 2026 | [Solicitation (Updated)] Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO) |
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