Synthesis of HNMT, NNMT intermediates and PK
| Location: | Maryland |
|---|---|
| Posted: | Aug 12, 2025 |
| Due: | Aug 19, 2025 |
| Agency: | HEALTH AND HUMAN SERVICES, DEPARTMENT OF |
| Type of Government: | Federal |
| Category: |
|
| Solicitation No: | 75N95025Q00236 |
| Publication URL: | To access bid details, please log in. |
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- Contract Opportunity Type: Presolicitation (Original)
- Original Published Date: Aug 12, 2025 06:48 am EDT
- Original Response Date: Aug 19, 2025 12:00 pm EDT
- Inactive Policy: 15 days after response date
- Original Inactive Date: Sep 03, 2025
-
Initiative:
- None
- Original Set Aside: No Set aside used
- Product Service Code: B504 - SPECIAL STUDIES/ANALYSIS- CHEMICAL/BIOLOGICAL
-
NAICS Code:
- 541380 - Testing Laboratories and Services
-
Place of Performance:
Rockville , MD 20850USA
NCATS is in need of custom synthesis and bioanalytical services in internal projects
focused on developing small molecule inhibitors of physiological small molecule
methyltransferases. NACTS is pursuing small molecules in two projects where
methyltransferases are implicated in disease. NCATS requires key intermediates that
will allow for the lab to scale up lead compounds or make analogs. NCATS also requires
exposure data in various tissues of interest to gauge compound concentrations to select
compounds for POC.
100g of N-(pyridin-3-yl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-e][1,4]diazepin-8-amine
100g of (tert-butyl (R)-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3- yl)piperidine-1-
carboxylate.
Mouse PK on at least 10 compounds with routes and tissues determined.
The final purity has to be >95% with optical purity >98%. Spectroscopic characterization
and analytical data will be required and verified.
- c/o 3WFN MSC 6012 301 N Stonestreet Ave
- Bethesda , MD 20892
- USA
- Andrew Varley
- andrew.varley@nih.gov
- Phone Number 3018275851
- Joshua T. Lazarus
- Josh.Lazarus@nih.gov
- Phone Number 3018276923
- Aug 12, 2025 06:48 am EDTPresolicitation (Original)
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