Peptide Synthesizer

Binghamton University intends to procure one (1) peptide synthesizer. The required specifications are as follows:

The System must be able to synthesize up to 4 unique sequences in parallel or sequentially using different programs.

The System must be able to use in situ activation or pre-activation methods for couplings.

The System must be capable of special chemistries such as conjugations and metal catalysts that require a fully inert and pressurized nitrogen gas environment.

The System must be upgradeable, capable of being upgraded to have a total of 6 reaction vessels, with independent heating agitation shaking, and independent real-time UV monitoring on all channels.

The System must use up to 4 independent reaction vessels when synthesizing unique peptides either in parallel or sequentially to avoid cross-contamination between unique syntheses.

The System must be capable of using disposable polypropylene(PP) reactions vessels as well as glass reaction vessels in multiple sizes to accommodate different reaction scales.

The System must allow for unaided visual inspection of all reactions and mixing operations during the synthesis.

The System must have a total reaction scale of 0.005 mmol to 6 mmol

The System must be capable of fully automated on-board cleavage of the peptide from solid support after synthesis, without implementing a stand-alone module or increase the System footprint.

The System must be capable of reassigning one or all cleave collect positions to be an amino acid single-shot position for delivery of specialty amino acids.

The system must be capable of agitating the contents of the reaction vessel by nitrogen bubbling, vortex mixing, and a combination of these methods.

All fluid transfers should be made using inert nitrogen, and all fluid measurements should be performed using a combination of fixed loop liquid metering with optical sensors.

The System must be capable of including independent safe induction heating (Patent number 10,695,739 B2) on each reaction vessel up to 90°C.

The system must be capable of including Intellisynth (Patent number 8,535,947 B2) real-time UV monitoring system on each channel.

In the event of an error, the system must be capable of washing the resin with a designated safe solvent and performing a drying step under nitrogen to prevent peptide degradation.

The System must offer 8 solvent/reagent positions.

The System must offer 27 amino acid reservoir positions, accommodating 10 mL single shot vials, 120 or 400 mL amino acid reservoirs.

The System must have an integrated computer in the instrument to save desktop space as well as have a chemically resistant touch screen interface.

The System must log real time operations, including temperature and UV monitoring data, and print to pdf or paper.

The System must offer different levels of user access. These might include Administrator, Designer and Runner to protect the integrity of the log file and program files.

The System must be capable of sending an email as a status message or on error.