UCSF Benioff Child Hosp Oakland-Hemoglobinopathies Testing

The Michigan Department of Health and Human Services, Bureau of Laboratories (MDHHS-BOL) intends to procure confirmatory testing conducted on dried blood spots for specific analytes related to hemoglobinopathies that is part of newborn screening, and the interpretation of the results from UCSF Benoiff Children's Hospital. The needed hemoglobin mutation analysis must include: seven common deletions (--SEA/, --FIL/, --THAI/, --MED/, --20.5/, - 3.7/, - 4.2/), and CS/) as well as Constant Spring, Alpha multiplex ligation-dependent probe amplification (MLPA), Beta sequencing, Beta MLPA, and Hereditary persistence of fetal hemoglobin (HPFH). The Childrens Hospital Oakland Research Institute (CHORI) is the only service provider who conducts these tests on dried blood spots, and provides the appropriate interpretation.