ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening

Location: Federal
Posted: Oct 7, 2026
Due: Oct 7, 2026
Agency: HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Type of Government: Federal
Category:
  • A - Research and development
Solicitation No: ARPA-H-SOL-26-165
Publication URL: To access bid details, please log in.
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ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening
Active
Contract Opportunity
Notice ID
ARPA-H-SOL-26-165
Related Notice
Department/Ind. Agency
HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Sub-tier
NATIONAL INSTITUTES OF HEALTH
Office
ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)
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General Information View Changes
  • Contract Opportunity Type: Solicitation (Updated)
  • Updated Published Date: Oct 07, 2026 01:52 pm EDT
  • Original Published Date: Sep 16, 2026 03:17 pm EDT
  • Updated Date Offers Due: Oct 07, 2026 05:00 pm EDT
  • Original Date Offers Due: Oct 07, 2026 02:00 pm EDT
  • Inactive Policy: 15 days after date offers due
  • Updated Inactive Date: Oct 22, 2026
  • Original Inactive Date: Oct 22, 2026
  • Initiative:
    • None
Classification
  • Original Set Aside:
  • Product Service Code: AN13 - HEALTH R&D SERVICES; HEALTH CARE SERVICES; EXPERIMENTAL DEVELOPMENT
  • NAICS Code:
    • 541714 - Research and Development in Biotechnology (except Nanobiotechnology)
  • Place of Performance:
Description View Changes

The Advanced Research Projects Agency for Health (ARPA-H) Comprehensive Organ System Modeling in Outer Space (COSMOS) Initiative aims to definitively prove or disprove if exposure to microgravity in Low Earth Orbit (LEO) truly accelerates tissue aging across brain, cardiac, uterine, and kidney tissue types and across several adult age brackets. Provided Tissue Aging Rate in Space (TARIS) exceeds Tissue Aging Rate on Earth (TAROE) at a rate that exceeds the on Earth breakeven cost for new drug R&D, COSMOS will create a first-in-class platform for fully autonomous, high-throughput drug screening in LEO that would be more cost effective and faster than new drug R&D on Earth.



ARPA-H anticipates multiple Other Transaction awards resulting from this announcement.



Interested parties are invited to download and review the attached COSMOS Innovative Solutions Opening (ISO) ARPA-H-SOL-26-165



Amendment 01 – 17 September 2026: This amendment includes updated hyperlinks and information on the updated Solutions summary portal.



Questions and Answers – 21 September 2026: This Q&A is provided for informational purposes only and does not amend the solicitation. All other questions are due by 23 September 2026 at 5:00PM ET.



Amendment 02 – 23 September 2026: This amendment includes updates to Section 3, COSMOS Details; Section 4, Mandatory Experimental Design; as well as Correction to Figure 2.



Questions and Answers – 25 September 2026: This Q&A is provided for informational purposes only and does not amend the solicitation.



Amendment 03 – 07 October 2026: This amendment extends the submission time, now due 07 October 2026, 5:00pm ET.




Attachments/Links
Contact Information
Contracting Office Address
  • 1301 K Street NW Suite 1200 West
  • Washington , DC 20005
  • USA
Primary Point of Contact
Secondary Point of Contact


History

Related Document

Sep 16, 2026[Solicitation (Original)] ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening
Sep 17, 2026[Solicitation (Updated)] ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening
Sep 21, 2026[Solicitation (Updated)] ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening
Sep 23, 2026[Solicitation (Updated)] ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening
Sep 25, 2026[Solicitation (Updated)] ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening
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